What song really gets to you the most?

Pretty straightforward question I hope.

What song, whenever played, automatically just speaks to you? Whether
it's positively or negatively, which song really hits you the hardest,
and lets your emotions show?

For me, it has to be Alicia Keys' "Pray For Forgiveness." Excuse me
for being a little maudlin here, but every time I play it, it reminds
me of how alone I am most of the time.